产品货号：
Z10834
中文名称：
(Mouse) NOTCH1抗体
英文名称：
Anti-(Mouse) NOTCH1 Antibody (C-term)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-(Mouse) NOTCH1 Antibody (C-term) |
| 指标别名 | hN1;Notch 1;NOTCH1;TAN1 |
| 克隆性 | Polyclonal |
| 检验物种 | mouse |
| 应用范围 | WB |
| 基因名称 | Notch1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This Mouse Notch1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2403-2437 amino acids from the C-terminal region of Mouse Notch1. |
| 计算分子量 | 271kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Functions as a receptor for membrane-bound ligands Jagged1,Jagged2 and Delta1 to regulate cell-fate determination.Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.Affects the implementation of differentiation,proliferation and apoptotic programs.Involved in angiogenesis;negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.Involved in the maturation of both CD4+ and CD8+ cells in the thymus.Important for follicular differentiation and possibly cell fate selection within the follicle.During cerebellar development,functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.Represses neuronal and myogenic differentiation.May play an essential role in postimplantation development,probably in some aspect of cell specification and/or differentiation.May be involved in mesoderm development,somite formation and neurogenesis.May enhance HIF1A function by sequestering HIF1AN away from HIF1A.Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury.Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). |
| Uniprot ID | Q01705 |
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